Abstract
Significant changes of the aromatase and 5 alpha-reductase hypothalamic activity were found in juvenile prenatally stressed male Wistar rats. The blood plasma testosterone level increased following niftolide (NF) or 1, 4, 6-androstatine-3, 17-dione (ATD) administration. Prenatal stress seems to exert a modifying effect upon the regulating mechanisms of the pituitary gonadotropin function, lowering the functional reserves of the hypothalamo-hypophyseal-testicular axis in pre- and postpubertal male rats.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Androgen Antagonists / pharmacology
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Androstatrienes / pharmacology
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Animals
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Aromatase / metabolism
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Aromatase Inhibitors
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Cholestenone 5 alpha-Reductase
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Enzyme Inhibitors / pharmacology
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Female
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Flutamide / pharmacology
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Gonadotropins, Pituitary / physiology*
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Hypothalamo-Hypophyseal System / drug effects
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Hypothalamo-Hypophyseal System / enzymology
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Hypothalamo-Hypophyseal System / physiopathology
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Male
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Oxidoreductases / metabolism
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Pregnancy
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Prenatal Exposure Delayed Effects*
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Rats
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Rats, Wistar
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Sexual Maturation / drug effects
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Sexual Maturation / physiology
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Stress, Physiological / enzymology
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Stress, Physiological / physiopathology*
Substances
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Androgen Antagonists
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Androstatrienes
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Aromatase Inhibitors
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Enzyme Inhibitors
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Gonadotropins, Pituitary
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androsta-1,4,6-triene-3,17-dione
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Flutamide
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Oxidoreductases
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Aromatase
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Cholestenone 5 alpha-Reductase