Breast cancer prognostic significance of some modified urinary nucleosides

Cancer Lett. 1996 Nov 29;108(2):157-62. doi: 10.1016/s0304-3835(96)04393-5.

Abstract

The prognostic significance of six urinary modified nucleosides, 5-methylcytidine (5-MeCyd), 4-acetylcytidine (4-AcCyd), 1-methylinosine (1-MeIno), 1-methyladenosine (1-MeAdo), 7-methylguanosine (7-MeGua) and pseudouridine (psi-Urd) was evaluated in 68 breast cancer patients of the specialized cancer hospital of Lyon (France). Excretions of 1-MeIno and 1-MeAdo were significantly higher in patients hospitalized in the medical rather than surgical ward, reflecting more advanced disease, and also among patients who died within 5 years of follow-up as compared to those still alive. These results suggest an unfavourable prognostic significance of high urinary excretion of 1-MeIno and 1-MeAdo in breast cancer patients.

MeSH terms

  • Biomarkers, Tumor / urine*
  • Breast Neoplasms / pathology
  • Breast Neoplasms / urine*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nucleosides / urine*

Substances

  • Biomarkers, Tumor
  • Nucleosides