Model of a thalamocortical neurone with dendritic voltage-gated ion channels

Neuroreport. 1996 Nov 4;7(15-17):2655-8. doi: 10.1097/00001756-199611040-00049.

Abstract

To investigate the functional role of dendrites of thalamocortical neurones, we have used our one-compartmental model to construct a multi-compartmental model with dendritic regions chosen according to a representative soma-to-dendritic terminal path of an X cell of the cat dorsal lateral geniculate nucleus. The multi-compartmental model with dendritic low-threshold Ca2+ and delayed rectifier K+ channels yields more accurate results than the one-compartmental model when simulating tonic firing and oscillatory activities, and provides a useful means for the study of propagation of excitation on the dendrites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cats
  • Dendrites / physiology*
  • Ion Channels / physiology*
  • Models, Neurological
  • Thalamus / physiology*

Substances

  • Ion Channels