Abstract
A single contig spanning the entire mouse immunoglobulin kappa light chain (Igk) locus on chromosome 6 has been established using yeast and bacterial artificial chromosome clones. Detailed mapping of the Igk locus indicates that a member of the Igk-V2 gene family, located about 3.5 megabases upstream of the Igk-J-C complex, is the most distal functional Igk-V gene. Sequence analyses of Igk-V genes and anonymous DNA segments provide indications for internal duplications at the 5' end of the Igk-V locus and identify the likely origin of Igk-V orphon gene clusters located elsewhere in the mouse genome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Base Sequence
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Chromosome Mapping*
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Chromosomes, Artificial, Yeast*
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Cricetinae
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DNA
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DNA Transposable Elements
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Hybrid Cells
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Immunoglobulin kappa-Chains / genetics*
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Mice
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Molecular Sequence Data
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Multigene Family
Substances
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DNA Transposable Elements
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Immunoglobulin kappa-Chains
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DNA
Associated data
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GENBANK/Z72355
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GENBANK/Z72356
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GENBANK/Z72357
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GENBANK/Z72358
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GENBANK/Z72359
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