Abstract
From Jatropha cilliata M. Arg., a Peruvian medicinal plant, isoorientin and orientin were isolated as anxiolytic components by using the isolation guide of anti-conflict effect in mice. Several related flavonoids were also tested for this effect. Another bioassay-guided isolation using the acetic acid-induced writhing method gave a coumarin compound, fraxetin, as an analgesic principle.
MeSH terms
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Analgesics / chemical synthesis
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Analgesics / pharmacology
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Analgesics, Non-Narcotic / pharmacology
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Animals
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Anti-Anxiety Agents / chemistry
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Anti-Anxiety Agents / isolation & purification*
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Anti-Anxiety Agents / pharmacology
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Behavior, Animal / drug effects
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Body Temperature / drug effects
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Conflict, Psychological
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Diazepam / pharmacology
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Dose-Response Relationship, Drug
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Electroshock
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Male
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Mass Spectrometry
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Mice
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Mice, Inbred Strains
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Peru
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Plants, Medicinal / chemistry*
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Rats
Substances
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Analgesics
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Analgesics, Non-Narcotic
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Anti-Anxiety Agents
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Diazepam