A case of bone marrow recurrence from gastric carcinoma after a nine-year disease-free interval

Jpn J Clin Oncol. 1996 Dec;26(6):472-5. doi: 10.1093/oxfordjournals.jjco.a023267.

Abstract

We present a case of very late and unusual recurrence of gastric cancer. Nine years following total gastrectomy for gastric carcinoma, a 57-year-old man presented with disseminated intravascular coagulation associated with bone marrow recurrence. The primary tumor was a signet ring cell carcinoma invading the subserosal layer with lymph node metastasis. The patient was treated with sequential administration of methotrexate and 5-fluorouracil and went into remission. After treatment, he survived 10 months. Autopsy revealed diffuse bone marrow infiltration and distant lymph node metastasis with signet ring carcinoma cells.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bone Marrow Neoplasms / diagnostic imaging
  • Bone Marrow Neoplasms / secondary*
  • Carcinoma, Signet Ring Cell / diagnostic imaging
  • Carcinoma, Signet Ring Cell / secondary*
  • Disseminated Intravascular Coagulation / etiology*
  • Fluorouracil / administration & dosage
  • Gastrectomy
  • Humans
  • Lymphatic Metastasis
  • Male
  • Methotrexate / administration & dosage
  • Middle Aged
  • Radionuclide Imaging
  • Stomach Neoplasms / pathology*
  • Stomach Neoplasms / surgery

Substances

  • Fluorouracil
  • Methotrexate