111In-octreotide scintigraphy in pituitary adenomas

Q J Nucl Med. 1995 Dec;39(4 Suppl 1):94-7.

Abstract

This study reports on 111In-octreotide scintigraphy in 20 patients affected with pituitary adenomas, including tracer uptake ratios and in vitro immunohistochemical characterization of the matostatin receptor state. 111In-octreotide uptake was already observed at 4 hours in 7/8 GH-secreting adenomas, in 5/7 non-secreting adenomas and in 1/5 prolactinomas. Concordance between the scan and the histochemical results was observed in all cases. The uptake ratios evaluated at 24 hours ranged from 2.3 to 4.2. The following conclusions were drawn: 1) 111In-octreotide is a suitable tracer to evaluate the somatostatin receptor state of pituitary adenomas; 2) Semi-quantitative measures of tracer uptake can be easily obtained with static planar scanning, but more refined techniques are needed for receptor kinetics evaluation; 3) This nuclear technique is a promising non-invasive tool to identify patients with somatostatin receptor positive pituitary adenomas who might potentially benefit from pre- and/or post-surgery cold octreotide medical treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma / diagnostic imaging*
  • Adenoma / drug therapy
  • Adenoma / metabolism
  • Adenoma / surgery
  • Antineoplastic Agents, Hormonal / therapeutic use
  • Human Growth Hormone / metabolism
  • Humans
  • Immunohistochemistry
  • Indium Radioisotopes* / pharmacokinetics
  • Octreotide / analogs & derivatives*
  • Octreotide / pharmacokinetics
  • Octreotide / therapeutic use
  • Pentetic Acid / analogs & derivatives*
  • Pentetic Acid / pharmacokinetics
  • Pituitary Neoplasms / diagnostic imaging*
  • Pituitary Neoplasms / drug therapy
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / surgery
  • Prolactinoma / diagnostic imaging
  • Prolactinoma / metabolism
  • Radionuclide Imaging
  • Radiopharmaceuticals* / pharmacokinetics
  • Receptors, Somatostatin / analysis

Substances

  • Antineoplastic Agents, Hormonal
  • Indium Radioisotopes
  • Radiopharmaceuticals
  • Receptors, Somatostatin
  • Human Growth Hormone
  • SDZ 215-811
  • Pentetic Acid
  • Octreotide