Auger-electron spectra of radionuclides for therapy and diagnostics

Acta Oncol. 1996;35(7):863-8. doi: 10.3109/02841869609104038.

Abstract

The present paper documents the calculation of radiation spectra and of radial dose distribution around a point source for 24 selected radionuclides. The radionuclides were ordered into three groups: Nuclides potentially useful for therapy by emission of Auger electrons: 51Cr, 64Cu, 67Ga, 73Se, 75Se, 77Br, 80mBr, 94Tc, 99mTc, 114mIn, 115mIn, 123I, 124I, 125I, 167Tm, 193mPt, and 195mPt, nuclides potentially useful for therapy by alpha-particles with additional emission of Auger electrons: 212Bi, 211At and 255Fm, and nuclides potentially useful for electron Auger-therapy with simultaneous PET diagnosis: 73Se, 94Tc and 124I. The calculations imply strongly the development of labelled DNA-seeking compounds useful as carrier for the Auger- and Coster-Kronig electron-emitting radionuclides.

MeSH terms

  • Half-Life
  • Linear Energy Transfer*
  • Models, Biological
  • Radiation Dosage
  • Radioisotopes* / classification
  • Radioisotopes* / therapeutic use

Substances

  • Radioisotopes