3-Heteroarylquinuclidin-2-ene derivatives as muscarinic antagonists: synthesis, structure-activity relationships and molecular modelling

Prog Brain Res. 1996:109:141-5. doi: 10.1016/s0079-6123(08)62095-6.

Authors

G Nordvall¹, B M Nilsson, S Sundquist, G Johansson, G Glas, L Nilvebrant, U Hacksell

Affiliation

¹ Department of Organic Pharmaceutical Chemistry, Uppsala University, Sweden.

PMID: 9009700
DOI: 10.1016/s0079-6123(08)62095-6

No abstract available

MeSH terms

Animals
Binding Sites
Cerebral Cortex / metabolism
Guinea Pigs
Kinetics
Models, Molecular
Molecular Conformation
Molecular Structure
Muscarinic Antagonists / chemical synthesis
Muscarinic Antagonists / chemistry*
Muscarinic Antagonists / pharmacology*
Myocardium / metabolism
Parotid Gland / metabolism
Protein Conformation
Quinuclidines / chemical synthesis
Quinuclidines / chemistry*
Quinuclidines / pharmacology*
Receptors, Muscarinic / chemistry
Receptors, Muscarinic / metabolism*
Structure-Activity Relationship
Urinary Bladder / metabolism

Substances

Muscarinic Antagonists
Quinuclidines
Receptors, Muscarinic