Case report of a 67-years-old man with cephalopancreatic carcinoma and a peculiar evolution, undergoing several operations. The diagnostic was established 3 years ago through a peroperative pancreatic bioptic puncture, followed by choledochoduodenostomy considering the tumor as inextirpable. After 2 1/2 years symptoms of high occlusion and upper digestive bleeding caused by duodenal invasion and a Wölfler precolic gastrojejunostomy was performed. After 4 month the upper digestive bleeding relapsed severely imposing the second reintervention (cephalic duodenopancreatectomy with a special montage). The evolution was favourable, the clinical, biological and imagistic control at 6 month showing the absence of recidive.