Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the pyrrolecarboxamide antitumour antibiotics

K Bielawski; D Bartulewicz; D Krajewska; A Rózański

Synthetic analogues of netropsin and distamycin. III. Synthesis of a pyridine analogue of the pyrrolecarboxamide antitumour antibiotics

Rocz Akad Med Bialymst. 1996;41(2):293-304.

Authors

K Bielawski¹, D Bartulewicz, D Krajewska, A Rózański

Affiliation

¹ Department of Organic Chemistry, Medical Academy of Białystok.

PMID: 9020541

Abstract

The synthesis of a new pyridine analogue of netropsin, N,N'-bis[6-(N-3-dimethylaminopropyl) carbamoylpyridin-2-yl] pyridine-2,5-dicarboxamide (VII) is described. The potential for use of VII as a carrier to place chemical functionalities into the minor groove of DNA which are capable of modifying DNA is discussed.

MeSH terms

Antibiotics, Antineoplastic / chemical synthesis*
Base Sequence
Binding Sites
Computer-Aided Design
DNA / chemistry
Distamycins / chemistry*
Drug Design
Models, Molecular
Netropsin / analogs & derivatives*
Nicotinic Acids / chemical synthesis*
Nicotinic Acids / chemistry
Picolinic Acids / chemical synthesis*
Picolinic Acids / chemistry
Sequence Analysis, DNA

Substances

Antibiotics, Antineoplastic
Distamycins
N,N'-bis(6-(N-3-dimethylaminopropyl)carbamoylpyridin-2-yl)pyridine-2,5-dicarboxamide
Nicotinic Acids
Picolinic Acids
Netropsin
stallimycin
DNA