Abstract
In a double-blind study, the effects of the interaction between the administration of amineptine versus placebo and repeated cycles of total sleep deprivation (TSD), which is thought to act through an enhancement in dopaminergic transmission, were analyzed. Twenty-two consecutively admitted patients with bipolar depression formed the study group. Repeated administrations of TSD significantly enhanced perceived mood levels in placebo-treated patients, while amineptine administration blocked the antidepressant action of TSD. Hypothesized changes in brain dopaminergic transmission attributable to amineptine pretreatment are discussed.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Antidepressive Agents, Tricyclic / pharmacology*
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Bipolar Disorder / physiopathology*
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Bipolar Disorder / psychology
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Brain / drug effects
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Brain / physiopathology
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Depressive Disorder / physiopathology*
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Depressive Disorder / psychology
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Dibenzocycloheptenes / pharmacology*
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Dopamine / physiology*
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Dopamine Agonists / pharmacology*
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Double-Blind Method
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Female
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Humans
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Male
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Middle Aged
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Sleep Deprivation / physiology*
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Synaptic Transmission / drug effects
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Synaptic Transmission / physiology
Substances
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Antidepressive Agents, Tricyclic
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Dibenzocycloheptenes
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Dopamine Agonists
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amineptin
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Dopamine