Abstract
The susceptibility of clinical isolates of methicillin-susceptible and -resistant staphylococci from cancer patients with central venous catheter bacteremia to quinupristin/dalfopristin, a semisynthetic streptogramin, was determined in vitro. Susceptibility of these isolates to nine other antistaphylococcal antibiotics was also determined for comparison. A total of 197 staphylococcal strains were tested from 1983 to 1992. Quinupristin/dalfopristin was bactericidal against all isolates, independent of their resistance to methicillin. Its activity was similar to that of vancomycin but superior to that of teicoplanin. Quinupristin/dalfopristin may prove to be an important addition to our armamentarium against catheter-related staphylococcal infections.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Anti-Infective Agents / pharmacology
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Antibiotics, Antitubercular / pharmacology
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Bacteremia / complications
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Bacteremia / microbiology
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Catheterization, Central Venous / adverse effects*
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Cefamandole / pharmacology
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Cephalosporins / pharmacology
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Ciprofloxacin / pharmacology
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Clindamycin / pharmacology
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Daptomycin / pharmacology
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Humans
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Methicillin / therapeutic use
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Methicillin Resistance
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Microbial Sensitivity Tests*
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Neoplasms / microbiology
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Novobiocin / pharmacology
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Oxacillin / pharmacology
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Penicillins / therapeutic use
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Rifampin / pharmacology
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects*
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Staphylococcus epidermidis / drug effects*
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Teicoplanin / pharmacology
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Vancomycin / pharmacology
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Virginiamycin / pharmacology*
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antibiotics, Antitubercular
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Cephalosporins
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Penicillins
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Virginiamycin
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quinupristin-dalfopristin
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Novobiocin
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Clindamycin
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Cefamandole
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Ciprofloxacin
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Teicoplanin
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Vancomycin
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Daptomycin
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Methicillin
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Oxacillin
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Rifampin