A case of drug eruption due to simultaneous sensitization with three different kinds of drugs

J Dermatol. 1996 Dec;23(12):899-901. doi: 10.1111/j.1346-8138.1996.tb02723.x.

Abstract

We reported a case of drug eruption induced by combined treatment with three different kinds of drugs, amoxapine, mexiletine hydrochloride and cefaclor. A 63-year-old Japanese woman suffering from 11 years of standing reflex sympathetic dystrophy developed multiple erythematous papules on her trunk and extremities after taking 14 kinds of drugs. The provocation challenge produced positive reactions to amoxapine, mexiletine hydrochloride, and cefaclor, but was negative to the other drugs. We discussed the mechanism of simultaneous sensitization to three different kinds of drugs in our case.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Amoxapine / adverse effects
  • Amoxapine / therapeutic use
  • Cefaclor / adverse effects
  • Cefaclor / therapeutic use
  • Cephalosporins / adverse effects
  • Cephalosporins / therapeutic use
  • Drug Eruptions / etiology*
  • Drug Eruptions / immunology
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / immunology
  • Female
  • Humans
  • Mexiletine / adverse effects
  • Mexiletine / therapeutic use
  • Middle Aged
  • Multiple Chemical Sensitivity / etiology*
  • Multiple Chemical Sensitivity / immunology
  • Patch Tests
  • Selective Serotonin Reuptake Inhibitors / adverse effects
  • Selective Serotonin Reuptake Inhibitors / therapeutic use

Substances

  • Cephalosporins
  • Serotonin Uptake Inhibitors
  • Mexiletine
  • Cefaclor
  • Amoxapine