Abstract
The genetic relationships between 88 meningococcal strains were analyzed by using the polymorphism of the pilA gene and the multilocus enzyme electrophoresis. While a good agreement was observed, correlation with antigenic formula (serogroup, serotype, and serosubtype) was incomplete. The inadequacy of serological classification alone in outbreak surveillance may be overcome by DNA-based approaches.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Bacterial Proteins / genetics
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Bacterial Typing Techniques
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DNA-Binding Proteins / genetics
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Disease Outbreaks
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Fimbriae Proteins*
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Genes, Bacterial*
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Humans
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Meningococcal Infections / epidemiology
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Meningococcal Infections / microbiology
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Molecular Epidemiology
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Neisseria meningitidis / classification
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Neisseria meningitidis / genetics*
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Neisseria meningitidis / isolation & purification
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Oxidoreductases*
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Polymerase Chain Reaction
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Polymorphism, Genetic*
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Serotyping
Substances
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Bacterial Proteins
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DNA-Binding Proteins
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Fimbriae Proteins
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Oxidoreductases
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pilB protein, Bacteria