Abstract
A study on the release of 17 beta-estradiol and progesterone from d,l-lactide and epsilon-caprolactone copolymer was performed. The copolymer was used in the form of microsphere, d,l-lactide content in the copolymer was 83%. It was found that nearly constant rate of hormone release during 100 days of experiment can be achieved by using this biodegradable material as a drug carrier.
MeSH terms
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Animals
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Biotransformation
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Delayed-Action Preparations
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Drug Carriers
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Estradiol / administration & dosage*
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Estradiol / analysis
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Estradiol / pharmacokinetics
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Male
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Microspheres
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Polyesters* / pharmacokinetics
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Progesterone / administration & dosage*
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Progesterone / analysis
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Progesterone / pharmacokinetics
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Rats
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Rats, Wistar
Substances
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Delayed-Action Preparations
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Drug Carriers
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Polyesters
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Progesterone
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Estradiol
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lactide-caprolactone copolymer