Treatment of relapsed non-Hodgkin's lymphoma after BEAM chemotherapy and autologous transplantation by BU/CY chemotherapy and salvage transplantation

Bone Marrow Transplant. 1997 Mar;19(5):527-8. doi: 10.1038/sj.bmt.1700690.

Abstract

We report a patient with centroblastic non-Hodgkin's MALT lymphoma of the stomach treated initially with surgery and post-operative chemotherapy and radiotherapy. First relapse was treated with high-dose BEAM chemotherapy and autologous peripheral blood stem cell transplantation (PBSCT). Second, systemic relapse was treated with high-dose BU/CY and second PBSCT. Today, the patient is in complete remission at 27+ months. The case indicates a curative potential for high-dose BU/CY chemotherapy as salvage therapy for relapsed high-grade lymphoma after BEAM and autologous PBSCT. This may have implications for the prevention as well as for the management of lymphoma relapse after high-dose chemotherapy (HDC) and autologous PBSCT.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Carmustine / administration & dosage
  • Cisplatin / administration & dosage
  • Combined Modality Therapy
  • Cyclophosphamide / administration & dosage
  • Cytarabine / administration & dosage
  • Doxorubicin / administration & dosage
  • Epirubicin / administration & dosage
  • Etoposide / administration & dosage
  • Granulocyte Colony-Stimulating Factor / therapeutic use
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Ifosfamide / administration & dosage
  • Injections, Spinal
  • Lymphoma, B-Cell, Marginal Zone / drug therapy
  • Lymphoma, B-Cell, Marginal Zone / radiotherapy
  • Lymphoma, B-Cell, Marginal Zone / surgery
  • Lymphoma, B-Cell, Marginal Zone / therapy*
  • Male
  • Melphalan / administration & dosage
  • Methotrexate / administration & dosage
  • Prednisone / administration & dosage
  • Recurrence
  • Remission Induction
  • Retreatment
  • Salvage Therapy
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / radiotherapy
  • Stomach Neoplasms / surgery
  • Stomach Neoplasms / therapy*
  • Transplantation Conditioning
  • Tumor Lysis Syndrome / etiology
  • Vincristine / administration & dosage

Substances

  • Cytarabine
  • Granulocyte Colony-Stimulating Factor
  • Epirubicin
  • Vincristine
  • Etoposide
  • Doxorubicin
  • Cyclophosphamide
  • Cisplatin
  • Melphalan
  • Carmustine
  • Ifosfamide
  • Prednisone
  • Methotrexate

Supplementary concepts

  • BEAM regimen
  • CHOP protocol
  • VIP-E protocol