Arousal and inhibition of human NK cells

Immunol Rev. 1997 Feb:155:145-54. doi: 10.1111/j.1600-065x.1997.tb00947.x.

Abstract

NK cells express receptors for polymorphic MHC class I molecules that inhibit killing of potential target cells bearing appropriate class I allotypes. Here we review the membrane receptors on human NK cells that are known to initiate cell-mediated cytotoxicity and demonstrate regulation of these responses by the killer cell inhibitory (KIR) receptors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Antigens, Ly*
  • Humans
  • Killer Cells, Natural / drug effects
  • Killer Cells, Natural / metabolism*
  • Lectins, C-Type
  • Lymphocyte Activation* / drug effects
  • Membrane Glycoproteins / physiology*
  • Molecular Sequence Data
  • Receptors, Immunologic / physiology*
  • Receptors, NK Cell Lectin-Like
  • Suppressor Factors, Immunologic / physiology*

Substances

  • Antigens, Ly
  • Lectins, C-Type
  • Membrane Glycoproteins
  • Receptors, Immunologic
  • Receptors, NK Cell Lectin-Like
  • Suppressor Factors, Immunologic