Abstract
Benzophenones (BP) and related aryl ketone photophores have become established as the photoactivatable group of choice for high-efficiency covalent modification of hydrophobic regions of binding proteins, including enzymes and receptors that recognize peptide hormones, (oligo) nucleotides and nucleosides, phosphoinositides, inositol polyphosphates and a wide variety of therapeutic molecules. This review presents the advantages of BP as photoaffinity labels and provides specific examples from the last 3 years of applications of BP-containing ligands used in biochemistry.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Affinity Labels / chemical synthesis
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Affinity Labels / chemistry*
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Benzophenones / chemical synthesis
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Benzophenones / chemistry*
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Peptides / analysis*
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Pharmaceutical Preparations / analysis*
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Phosphatidylinositols / analysis*
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Photobiology / methods*
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Photosensitizing Agents / chemical synthesis
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Photosensitizing Agents / chemistry*
Substances
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Affinity Labels
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Benzophenones
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Peptides
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Pharmaceutical Preparations
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Phosphatidylinositols
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Photosensitizing Agents
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benzophenone