[Effect of non-radioactive thymidine on mitosis in bone marrow]

Arch Invest Med (Mex). 1977;8(2):155-60.
[Article in Spanish]

Abstract

Intraperitoneal administration of thymidine into albino mouse (strains CD-1) at dose of 4.8 mg (180 mg/kg) increases mitotic rate in bone marrow at 6, 9 and 12 hours; this effect begins at 3 hours and disappears at 24 hours. It is suggested that thymidine increases mitotic rate by an indirect mechanism, stimulating DNA synthesis during S phase through activation of thymidoquinase. Control group (saline solution without thymidine) showed reduction in mitotic rate; such a finding has no explanation as yet.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Bone Marrow / drug effects*
  • DNA / biosynthesis
  • Mitosis / drug effects*
  • Rats
  • Thymidine / pharmacology*
  • Thymidine Kinase / pharmacology

Substances

  • DNA
  • Thymidine Kinase
  • Thymidine