Dapsone and severe hypoalbuminaemia. A report of two cases

Lancet. 1979 Sep 29;2(8144):662-4. doi: 10.1016/s0140-6736(79)92066-x.

Abstract

Severe hypoalbuminaemia developed in two patients on long-term dapsone treatment for dermatitis herpetiformis. The patients had been treated with dapsone for 3 and 11 years before the syndrome developed and both recovered completely when dapsone was withdrawn. Albumin-turnover studies revealed a great increase in intravascular albumin catabolism and a modest decrease in synthesis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blood Protein Disorders / chemically induced*
  • Blood Protein Disorders / diagnosis
  • Dapsone / administration & dosage
  • Dapsone / adverse effects*
  • Dermatitis Herpetiformis / drug therapy
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Serum Albumin / analysis*
  • Serum Albumin, Radio-Iodinated
  • Sodium / blood

Substances

  • Serum Albumin
  • Serum Albumin, Radio-Iodinated
  • Dapsone
  • Sodium