Abstract
Two preterm infants with extensive periventricular leukomalacia (PVL) were examined by [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) at the corrected ages of 18 and 34 days. They showed similar clinical courses including oculoclonic seizure, hypsarrhythmia and severe mental retardation, in addition, to spastic quadriplegia. FDG-PET study of these two infants with severe PVL disclosed poorly developed metabolic activity in the primary sensorimotor cortex, while the MRI images displayed only periventricular white matter lesions.
Conclusions:
Positron emission tomography may disclose cortical involvement in infants with severe periventricular leukomalacia.
MeSH terms
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Blood Glucose / metabolism*
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Brain Mapping
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Brain Stem / diagnostic imaging
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Brain Stem / physiopathology
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Deoxyglucose / analogs & derivatives
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Deoxyglucose / metabolism
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Female
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Fluorodeoxyglucose F18
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Humans
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Infant, Newborn
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Infant, Premature, Diseases / diagnostic imaging*
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Infant, Premature, Diseases / physiopathology
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Leukomalacia, Periventricular / diagnostic imaging*
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Leukomalacia, Periventricular / physiopathology
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Male
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Motor Cortex / diagnostic imaging
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Motor Cortex / physiopathology
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Pregnancy
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Pregnancy, Multiple
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Somatosensory Cortex / diagnostic imaging
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Somatosensory Cortex / physiopathology
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Spasms, Infantile / diagnostic imaging*
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Spasms, Infantile / physiopathology
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Tomography, Emission-Computed*
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Triplets
Substances
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Blood Glucose
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Fluorodeoxyglucose F18
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Deoxyglucose