A case of primary cutaneous cryptococcosis

Eur J Clin Microbiol Infect Dis. 1997 Feb;16(2):150-2. doi: 10.1007/BF01709474.

Abstract

The case of a 77-year-old man in whom a large digital ulcer with undermined edges was due to cutaneous infection by Cryptococcus neoformans variety neoformans serotype D, probably following direct inoculation, is reported. Long-term steroid treatment for chronic obstructive pulmonary disease may have been a risk factor. A 12-day course of intravenous amphotericin B at a cumulative dose of 750 mg, followed by oral fluconazole at a daily dose of 600 mg for six weeks, resulted in healing of the skin lesion. Manifestations of primary cutaneous cryptococcosis in immunocompetent or immunocompromised patients are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Aged
  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Cryptococcosis / diagnosis*
  • Cryptococcosis / drug therapy
  • Cryptococcus neoformans*
  • Dermatomycoses / diagnosis*
  • Dermatomycoses / drug therapy
  • Fingers / microbiology*
  • Fluconazole / administration & dosage
  • Fluconazole / therapeutic use
  • Humans
  • Immunocompromised Host
  • Lung Diseases, Obstructive / complications
  • Lung Diseases, Obstructive / drug therapy
  • Male
  • Steroids / adverse effects
  • Steroids / therapeutic use

Substances

  • Antifungal Agents
  • Steroids
  • Amphotericin B
  • Fluconazole