Abstract
Using the conflict drinking Vogel test in rats as a model we examined the anxiolytic-like activity of (RS)-alpha-methylserine-O-phosphate (MSOP) and (RS)-alpha-methylserine-O-phosphate-monophenyl ester (MSOPPE), the antagonists of group III and II of mGluR, respectively, after their intrahippocampal administration. The results indicated that MSOP produced a dose dependent anticonflict effect in rats.
MeSH terms
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Animals
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Anti-Anxiety Agents / administration & dosage
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Anti-Anxiety Agents / pharmacology*
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Conflict, Psychological
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Drinking Behavior / drug effects
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Hippocampus
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Male
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Microinjections
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Organophosphorus Compounds / administration & dosage
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Organophosphorus Compounds / pharmacology*
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Rats
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Rats, Wistar
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Receptors, Metabotropic Glutamate / antagonists & inhibitors*
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Serine / analogs & derivatives
Substances
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Anti-Anxiety Agents
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Organophosphorus Compounds
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Receptors, Metabotropic Glutamate
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Serine