Effect of glycine on antidepressant- and anxiolytic-like action of 1-aminocyclopropanecarboxylic acid (ACPC) in rats

Pol J Pharmacol. 1996 Nov-Dec;48(6):627-9.

Abstract

Glycine (800 mg/kg ip) abolished the antimmobility effect of 1-aminocyclopropanecarboxylic acid (ACPC) given both ip (400 mg/kg) and ihp (30 micrograms) in the forced swimming test in rats, but did not affect the anticonflict activity of ACPC (200 mg/kg ip or 10 micrograms ihp) in the conflict drinking test.

MeSH terms

  • Amino Acids / administration & dosage
  • Amino Acids / toxicity*
  • Amino Acids, Cyclic*
  • Animals
  • Anti-Anxiety Agents / toxicity*
  • Antidepressive Agents / toxicity*
  • Disease Models, Animal
  • Glycine / administration & dosage
  • Glycine / pharmacology*
  • Glycine / therapeutic use
  • Injections, Intraperitoneal
  • Male
  • Physical Conditioning, Animal
  • Rats
  • Rats, Wistar

Substances

  • Amino Acids
  • Amino Acids, Cyclic
  • Anti-Anxiety Agents
  • Antidepressive Agents
  • 1-aminocyclopropane-1-carboxylic acid
  • Glycine