Nuclear cardiology services increasingly are being provided in private-practice cardiology office settings. Because training programs are hospital based, trainees in nuclear cardiology may find only limited guidance on how to set up a private-practice nuclear laboratory. Furthermore, there is no literature to date advancing "models" for such facilities that might be useful for practice managers. The purpose of this review is to address common issues related to setting up and administering a nuclear cardiology laboratory in a private-practice cardiology office.