Abstract
Calcinosis cutis, an uncommon disorder characterized by hydroxyapatite crystals of calcium phosphate deposited in the skin, has been described infrequently in childhood. Classically, it is divided into dystrophic, metastatic, and idiopathic types. We report an 8-year-old girl with hyperphosphatemia secondary to a tumor lysis syndrome, who developed a localized soft tissue calcification over a previous lesion of ecthyma gangrenosum. Intravenous infusion of calcium gluconate was probably the precipitating factor. Our case illustrates that several etiopathogenic mechanisms may be simultaneously involved in calcinosis cutis.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Calcinosis / chemically induced
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Calcinosis / etiology
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Calcinosis / metabolism
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Calcinosis / pathology*
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Calcium Gluconate / adverse effects
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Calcium Phosphates / metabolism
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Child
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Crystallization
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Durapatite / metabolism
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Ecthyma / drug therapy
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Ecthyma / pathology
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Female
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Humans
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Phosphates / blood
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
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Skin / metabolism
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Skin Diseases / chemically induced
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Skin Diseases / etiology
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Skin Diseases / metabolism
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Skin Diseases / pathology*
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Tumor Lysis Syndrome / complications
Substances
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Calcium Phosphates
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Phosphates
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alpha-tricalcium phosphate
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tetracalcium phosphate
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calcium phosphate, monobasic, anhydrous
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Durapatite
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calcium phosphate
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calcium phosphate, dibasic, anhydrous
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Calcium Gluconate