Abstract
In this prospective study of enteric fever, 22 patients received 400 mg of pefloxacin twice daily for 5 days (group A) and 24 received 400 mg of pefloxacin twice daily for 7 days (group B). Causative microorganisms were Salmonella typhi (8 in group A, 11 in group B) and Salmonella paratyphi B (14 in group A, 13 in group B). The clinical cure and bacterial eradication rates were 96% (21 of 22) in group A and 100% in group B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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4-Quinolones*
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Adolescent
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Adult
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Aged
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Anti-Infective Agents / administration & dosage
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Anti-Infective Agents / therapeutic use*
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Drug Administration Schedule
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Female
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Fluoroquinolones*
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Humans
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Male
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Middle Aged
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Paratyphoid Fever / drug therapy*
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Pefloxacin
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Prospective Studies
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Quinolones / administration & dosage
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Quinolones / therapeutic use*
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Salmonella paratyphi B*
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Treatment Outcome
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Typhoid Fever / drug therapy*
Substances
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4-Quinolones
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Anti-Infective Agents
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Fluoroquinolones
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Quinolones