Abstract
A 13-year-old, neutered male greyhound was presented with severe hematemesis and hematochezia following only three doses of buffered aspirin that were within therapeutic recommendations. Transfusion of seven units of whole blood was required to stabilize the patient. Diagnostic evaluation failed to reveal an underlying disease state that could have predisposed the dog to massive gastric hemorrhage. This is the first report of buffered aspirin causing clinically significant disease during routine administration.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
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Aspirin / adverse effects*
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Blood Vessels / drug effects
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Blood Vessels / pathology
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Dog Diseases / chemically induced*
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Dog Diseases / pathology
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Dogs
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Dose-Response Relationship, Drug
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Gastric Mucosa / chemistry
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Gastric Mucosa / metabolism
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Gastric Mucosa / pathology
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Gastrointestinal Hemorrhage / chemically induced
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Gastrointestinal Hemorrhage / pathology
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Gastrointestinal Hemorrhage / veterinary*
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Histamine / analysis
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Histamine / metabolism
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Hydrogen-Ion Concentration
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Male
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Prostaglandins / analysis
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Prostaglandins / metabolism
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Stomach Diseases / chemically induced
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Stomach Diseases / pathology
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Stomach Diseases / veterinary*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Prostaglandins
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Histamine
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Aspirin