Abstract
The anticapsular antibody response of Chilean infants to a single dose of Haemophilus influenzae type b capsular polysaccharide-tetanus toxoid conjugate, vaccine is substantially higher than that observed among infants of similar age from the USA. Comparison of selected demographic and environmental factors indicates that low maternal education and a greater number of persons in the home are significantly associated with the superior responder phenotype. High anticapsular antibody responses were associated with high antibody responses to tetanus toxoid, the carrier protein in this conjugate, but not to diphtheria toxoid. These data suggest that environmental factors may enhance the magnitude of the primary antibody response to PRP-T vaccine.
Publication types
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Clinical Trial
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Clinical Trial, Phase II
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antibodies, Bacterial / biosynthesis*
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Chile / epidemiology
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / immunology*
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Humans
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Infant
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Tetanus Toxoid / administration & dosage
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Tetanus Toxoid / immunology*
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United States / epidemiology
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Vaccines, Conjugate / administration & dosage
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Vaccines, Conjugate / immunology
Substances
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Antibodies, Bacterial
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
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Tetanus Toxoid
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Vaccines, Conjugate