Abstract
It has been suggested that the association between the development of hypertension and a combination of low birth weight and high placental weight can be explained by variations in expression of NAD+-dependent 11beta-hydroxysteroid dehydrogenase (11-HSD2 or 11-HSD K) in the placenta. Enzymatic activity and mRNA levels of 11-HSD2 were measured in 111 human placentas taken from normal births. There were no correlations between either 11-HSD2 activity or mRNA levels and either fetal or placental weight. These studies suggest that variations in placental 11-HSD activity do not influence fetal or placental weight in humans.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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11-beta-Hydroxysteroid Dehydrogenases
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Adolescent
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Adult
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Birth Weight*
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Choriocarcinoma
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Cortisone / metabolism
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Female
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Humans
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Hydroxysteroid Dehydrogenases / biosynthesis
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Hydroxysteroid Dehydrogenases / metabolism*
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Infant, Low Birth Weight
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Infant, Newborn
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Isoenzymes / biosynthesis
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Isoenzymes / metabolism*
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Organ Size
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Placenta / anatomy & histology*
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Placenta / enzymology*
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Pregnancy
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RNA, Messenger / metabolism
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / metabolism
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Reference Values
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Risk Factors
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Transfection
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Tumor Cells, Cultured
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Uterine Neoplasms
Substances
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Isoenzymes
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RNA, Messenger
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Recombinant Proteins
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Hydroxysteroid Dehydrogenases
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11-beta-Hydroxysteroid Dehydrogenases
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Cortisone