Abstract
Conventional risk factors have very low predictive power in identifying haemodialysis patients at high risk of vascular accidents. A role for apolipoprotein E isotypes was looked for in a small, but rigorously defined, cohort of longterm haemodialysis patients. In individuals with high vascular risk, as identified by higher common carotid intima/media thickness, we found an excess of apolipoprotein E4 alleles. This preliminary result requires confirmation in large patient cohorts.
MeSH terms
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Adult
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Aged
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Alleles*
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Apolipoprotein E4
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Apolipoproteins E / genetics*
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Apolipoproteins E / physiology
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Arteriosclerosis / etiology
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Arteriosclerosis / genetics
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Arteriosclerosis / pathology
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Carotid Artery, Common / diagnostic imaging
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Carotid Artery, Common / pathology
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Cohort Studies
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Female
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Humans
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Lipids / blood
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Male
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Middle Aged
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Renal Dialysis / adverse effects*
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Risk Factors
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Ultrasonography
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Vascular Diseases / etiology*
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Vascular Diseases / genetics*
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Vascular Diseases / pathology
Substances
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Apolipoprotein E4
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Apolipoproteins E
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Lipids