Abstract
We studied the efficacies of ofloxacin, rifampin, and clindamycin in a Staphylococcus aureus abscess model and seven antimicrobial regimens in an intracellular killing assay. Ofloxacin plus rifampin was the most effective regimen in the abscess model, and rifampin and ofloxacin were the most active regimens in the intracellular killing assay.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Abscess / drug therapy*
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Animals
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Anti-Infective Agents / blood
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Anti-Infective Agents / therapeutic use*
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Antibiotics, Antitubercular / blood
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Antibiotics, Antitubercular / therapeutic use*
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Clindamycin / blood
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Clindamycin / therapeutic use*
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Microbial Sensitivity Tests
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Models, Biological
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Ofloxacin / blood
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Ofloxacin / therapeutic use*
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Rabbits
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Rats
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Rifampin / blood
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Rifampin / therapeutic use*
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Staphylococcal Infections / drug therapy*
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Staphylococcus aureus / drug effects
Substances
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Anti-Infective Agents
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Antibiotics, Antitubercular
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Clindamycin
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Ofloxacin
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Rifampin