Abstract
We examined 63 unrelated individuals from the United States for the Apa-LI polymorphism in intron 5 of the WT1 gene. Allele frequencies of 0.13 and 0.87 for the A and B alleles, respectively, and a heterozygosity index of 24% contrast sharply with previous data obtained in the Japanese population where allele frequencies of 0.55 and 0.45 for the A and B alleles and a heterozygosity index of 59% were reported. These data suggest genetic heterogeneity at the WT1 locus, which may contribute to the differences in the incidence of Wilms tumor between the two population groups.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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DNA-Binding Proteins / genetics
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Epistasis, Genetic
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Gene Frequency
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Genes, Wilms Tumor*
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Genetic Variation*
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Heterozygote
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Humans
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Incidence
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Introns / genetics*
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Japan / epidemiology
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Kidney Neoplasms / epidemiology
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Kidney Neoplasms / genetics
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Polymorphism, Restriction Fragment Length*
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Sequence Deletion
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Transcription Factors / genetics
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United States / epidemiology
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WT1 Proteins
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Wilms Tumor / epidemiology
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Wilms Tumor / genetics
Substances
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DNA-Binding Proteins
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Transcription Factors
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WT1 Proteins