Antidepressant treatment before hospitalization for major depression: often prescribed, often undertitrated

Pharmacol Res. 1997 Jan;35(1):33-6. doi: 10.1006/phrs.1996.0121.

Abstract

Fifty-three patients hospitalised for major depression were given a semi-structured interview to collect data allowing to consider the question of treatment in the period preceding hospitalisation. Twenty-one patients were discarded because they did not consult any physician (n = 5) or because they did it too late ( n = 11) or for they reached the threshold of major depression too late to allow sufficient time for efficacy of the treatment (n = 5). There remained a subsample of 20 potentially treatable patients. The majority of them refused their treatment (17%), were given no antidepressant treatment (14%) or at an insufficient dose (41%). If they received a sufficient dose, it was too lately (3%) or it was a maintenance therapy, which had not been modified in spite of a recurrence (14%), and finally only 10% of the potentially treatable patients could be considered as adequately treated, from a psychopharmacological point of view.

MeSH terms

  • Adult
  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / therapeutic use*
  • Depressive Disorder / drug therapy*
  • Female
  • Hospitalization
  • Humans
  • Interviews as Topic
  • Male
  • Middle Aged
  • Outcome and Process Assessment, Health Care
  • Patient Compliance
  • Quality of Health Care
  • Retrospective Studies

Substances

  • Antidepressive Agents