Primary adrenal lymphoma associated with adrenal insufficiency: a distinct clinical entity

Leuk Lymphoma. 1997 Jan;24(3-4):363-7. doi: 10.3109/10428199709039025.

Abstract

We describe a case of a 42 year old male who presented with Addison's disease resulting from primary lymphoma of the adrenals. Our case and a review of the literature indicates that this distinct entity has some unique clinical and radiologic features. In this entity, the lymphoma tends to be extranodal and have a poor prognosis. In addition, the computed tomography (CT) images have the unique appearance of enlargement of the adrenal gland with maintenance of the adreniform shape. We suggest that primary adrenal lymphoma is a distinct clinical entity and should be considered in patients with an elevated serum lactate dehydrogenase, characteristic CT findings and Addison's disease.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Addison Disease / blood
  • Addison Disease / etiology*
  • Adrenal Cortex Neoplasms / blood
  • Adrenal Cortex Neoplasms / complications*
  • Adrenal Cortex Neoplasms / diagnosis
  • Adrenal Cortex Neoplasms / drug therapy
  • Adrenal Cortex Neoplasms / pathology
  • Adrenal Gland Diseases / diagnosis
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers, Tumor / blood
  • Cosyntropin
  • Cyclophosphamide / administration & dosage
  • Dexamethasone / administration & dosage
  • Diagnosis, Differential
  • Doxorubicin / administration & dosage
  • Etoposide / administration & dosage
  • Eye Neoplasms / diagnostic imaging
  • Eye Neoplasms / drug therapy
  • Eye Neoplasms / pathology
  • Fatal Outcome
  • Humans
  • Hydrocortisone / blood
  • Hyperkalemia / etiology
  • Ifosfamide / administration & dosage
  • L-Lactate Dehydrogenase / blood
  • Lymphoma, T-Cell / blood
  • Lymphoma, T-Cell / complications*
  • Lymphoma, T-Cell / diagnosis
  • Lymphoma, T-Cell / drug therapy
  • Lymphoma, T-Cell / pathology
  • Male
  • Methotrexate / administration & dosage
  • Neoplasm Proteins / blood
  • Oculomotor Muscles / diagnostic imaging
  • Oculomotor Muscles / pathology
  • Prednisone / administration & dosage
  • Tomography, X-Ray Computed
  • Tuberculosis, Endocrine / diagnosis
  • Vincristine / administration & dosage

Substances

  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Cosyntropin
  • Vincristine
  • Etoposide
  • Dexamethasone
  • Doxorubicin
  • Cyclophosphamide
  • L-Lactate Dehydrogenase
  • Ifosfamide
  • Prednisone
  • Hydrocortisone
  • Methotrexate

Supplementary concepts

  • CHOP protocol