Abstract
It was established that selective ligands of the mu-opioid receptors DAGO and DALDA exhibit antiarrhythmic activity on a model of CACl2-induced arrhythmias when infused intravenously in a dose of 0.2 mg/kg. The autonomic nervous system does not take part in realization of the antiarrhythmic effect of DAGO and DALDA. It is supposed that this effect of DAGO and DALDA is associated with activation of cardiac mu-opioid receptors.
Publication types
-
English Abstract
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Anti-Arrhythmia Agents / therapeutic use*
-
Arrhythmias, Cardiac / chemically induced
-
Arrhythmias, Cardiac / drug therapy*
-
Arrhythmias, Cardiac / physiopathology
-
Atropine / pharmacology
-
Autonomic Nervous System / drug effects
-
Autonomic Nervous System / physiology*
-
Calcium Chloride
-
Disease Models, Animal*
-
Drug Evaluation, Preclinical
-
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
-
Enkephalins / therapeutic use*
-
Ganglionic Blockers / pharmacology
-
Hexamethonium / pharmacology
-
Male
-
Oligopeptides / therapeutic use*
-
Parasympatholytics / pharmacology
-
Rats
-
Rats, Wistar
-
Receptors, Opioid, mu / agonists*
-
Receptors, Opioid, mu / physiology
Substances
-
Anti-Arrhythmia Agents
-
Enkephalins
-
Ganglionic Blockers
-
Oligopeptides
-
Parasympatholytics
-
Receptors, Opioid, mu
-
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
-
tyrosyl-arginyl-phenylalanyl-lysinamide
-
Hexamethonium
-
Atropine
-
Calcium Chloride