Biclonal immunoglobulin M dysglobulinaemia: evolving aspects in a case of primary Sjögren's syndrome

Eur J Clin Chem Clin Biochem. 1997 Apr;35(4):287-90. doi: 10.1515/cclm.1997.35.4.287.

Abstract

The observation of suggestive clinical symptoms in a patient suffering from a Gougerot-Sjögren syndrome led to a search for a cryoglobulin. Unusual physico-chemical features of this cryoglobulin were discovered, using standard electrophoresis, immunoelectrophoresis, immunofixation and electroimmunotransfer. The main unusual finding was that the cryoprecipitate was made up of a biclonal IgM kappa associated to polyclonal IgG. Therefore, we suggest that this new form of cryoglobulin be classified as a subtype IIb, thus distinguishing two subtypes in the usual classification.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Antibodies, Monoclonal / blood
  • Antibodies, Monoclonal / chemistry
  • Cryoglobulinemia / etiology
  • Cryoglobulinemia / immunology*
  • Cryoglobulins / chemistry*
  • Female
  • Humans
  • Immunoelectrophoresis
  • Immunoglobulin M / blood*
  • Immunoglobulin M / chemistry
  • Sjogren's Syndrome / etiology
  • Sjogren's Syndrome / immunology*
  • Time Factors

Substances

  • Antibodies, Monoclonal
  • Cryoglobulins
  • Immunoglobulin M