Abstract
A study was carried out to examine the effect of an aqueous extract from immature fruit of Poncirus trifoliata L. (Rutaceae) (PTIFE) on the type I hypersensitivity reaction. Forty-eight hour PCA (passive cutaneous anaphylaxis) in rats was significantly inhibited by the oral administration of PTIFE (200 mg/kg). It also inhibited histamine release from rat peritoneal mast cells (RPMC) induced by mouse anti-dinitrophenyl (DNP)-IgE and dinitrophenyl-human serum albumin (DNP-HSA). These results suggest that PTIFE has anti-allergic action against the type I hypersensitivity reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Animals
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Antibodies / administration & dosage
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Antigens / immunology
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Antigens / toxicity
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Dinitrophenols / toxicity
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Disease Models, Animal
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Fruit / chemistry
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Fungicides, Industrial / toxicity
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Histamine Release / drug effects
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Humans
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Hypersensitivity, Immediate / drug therapy*
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Immunoglobulin E / immunology
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Injections, Intradermal
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Male
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Mast Cells / drug effects
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Mast Cells / metabolism
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Mice
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Passive Cutaneous Anaphylaxis / drug effects*
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Peritoneum / cytology
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Peritoneum / drug effects
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology
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Plant Extracts / therapeutic use*
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Rats
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Rats, Sprague-Dawley
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Serum Albumin / immunology
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Specific Pathogen-Free Organisms
Substances
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Antibodies
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Antigens
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Dinitrophenols
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Fungicides, Industrial
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Plant Extracts
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Serum Albumin
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Immunoglobulin E