Abstract
This paper reviews new findings on the biological functions of pseudorabies virus (PRV) proteins. It focuses on the role of PRV proteins in the pathogenicity, immunogenicity and transmission of PRV vaccine strains in pigs. Furthermore, it evaluates potential risks that are connected with the use of PRV vector strains. Special emphasis is placed upon the spread of genetically engineered vaccine strains within pigs or between pigs.
MeSH terms
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Animals
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Disease Vectors
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Genome, Viral
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Herpesvirus 1, Suid / genetics
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Herpesvirus 1, Suid / immunology
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Herpesvirus 1, Suid / pathogenicity*
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Protein Kinases / physiology
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Pseudorabies / immunology
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Pseudorabies / transmission
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Pseudorabies / virology*
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Pseudorabies Vaccines
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Ribonucleotide Reductases / physiology
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Swine
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Swine Diseases / immunology
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Swine Diseases / transmission
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Swine Diseases / virology*
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Thymidine Kinase / physiology
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Vaccines, Attenuated / adverse effects
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / standards
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Viral Envelope Proteins / physiology
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Viral Proteins / physiology*
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Viral Vaccines / adverse effects
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Viral Vaccines / genetics
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Viral Vaccines / standards
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Virulence
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Virus Assembly / physiology
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Virus Replication / physiology
Substances
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Pseudorabies Vaccines
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Vaccines, Attenuated
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Viral Envelope Proteins
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Viral Proteins
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Viral Vaccines
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pseudorabies virus glycoproteins
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Ribonucleotide Reductases
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Protein Kinases
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Thymidine Kinase