Abstract
In a series of nine cases of intra-oral granular cell tumors (GCTs) an attempt was made, using both histochemical and immunocytochemical methods, to determine whether these tumours show Schwann-cell or neuroendocrine differentiation. Positive immunostaining with protein gene product 9.5 (PGP 9.5), neurone-specific enolase (NSE) and S-100, in contrast to predominantly negative immunostaining in 12 cases of neurilemmoma of the head and neck, and a similar pattern of staining with luxol fast blue to five known neuroendocrine tumours, strongly suggests that granular cell tumors may be neuroendocrine in nature.
MeSH terms
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Adolescent
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Adult
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Biomarkers, Tumor
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Cell Lineage
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Chromogranin A
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Chromogranins / analysis
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Diagnosis, Differential
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Female
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Granular Cell Tumor / chemistry
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Granular Cell Tumor / pathology*
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Mouth Mucosa / chemistry
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Mouth Mucosa / pathology
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Mouth Neoplasms / chemistry
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Mouth Neoplasms / pathology*
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Myelin Basic Protein / analysis
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Neuroendocrine Tumors / chemistry
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Neuroendocrine Tumors / pathology*
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Phosphopyruvate Hydratase / analysis
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S100 Proteins / analysis
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Schwann Cells
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Thiolester Hydrolases / analysis
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Tongue Neoplasms / chemistry
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Tongue Neoplasms / pathology
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Ubiquitin Thiolesterase
Substances
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Biomarkers, Tumor
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Chromogranin A
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Chromogranins
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Myelin Basic Protein
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S100 Proteins
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Thiolester Hydrolases
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Ubiquitin Thiolesterase
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Phosphopyruvate Hydratase