Immunogenic and protective properties of haemagglutinin protein (H) of rinderpest virus expressed by a recombinant baculovirus

Vaccine. 1997 Apr-May;15(6-7):603-7. doi: 10.1016/s0264-410x(96)00244-7.

Abstract

The hemagglutinin (H) protein of Rinderpest virus expressed by a recombinant baculovirus used as a vaccine produced high titres of neutralizing antibody to Rinderpest virus in the vaccinated cattle, comparable to the levels produced by live attenuated vaccine. The immunized cattle were protected against a vaccine-virus challenge, as demonstrated by the failure of development of antibodies to N protein of the vaccine virus. The lack of replication of vaccine virus in the immunized cattle indicated that they are capable of showing a protective response if challenged with a virulent virus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / blood
  • Cattle
  • Chlorocebus aethiops
  • Genetic Vectors
  • Hemagglutinins, Viral / genetics
  • Hemagglutinins, Viral / immunology*
  • Nucleopolyhedroviruses*
  • Rinderpest virus / immunology*
  • Spodoptera / cytology
  • Vaccines, Attenuated / immunology
  • Vaccines, Synthetic / immunology*
  • Vero Cells
  • Viral Vaccines / immunology*

Substances

  • Antibodies, Viral
  • Hemagglutinins, Viral
  • Vaccines, Attenuated
  • Vaccines, Synthetic
  • Viral Vaccines