Abstract
This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HLA-A26- and HLA-A33-restricted and squamous cell carcinoma (SCC)-specific CTL; case 2, HLA-Cw0102-restricted and esophageal SCC-specific CTL; case 3, HLA-A24- and HLA-A26-restricted CTL recognizing histologically different tumor cells; and case 4, HLA-A26-restricted and esophageal SCC-specific CTL. These results suggest the existence of HLA class I-restricted and tumor-specific CTL in metastatic esophageal SCC.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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CD8-Positive T-Lymphocytes / immunology
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Carcinoma, Squamous Cell / immunology
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / secondary*
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Cytotoxicity Tests, Immunologic
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DNA, Complementary / genetics
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Esophageal Neoplasms / immunology
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Esophageal Neoplasms / pathology*
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HLA-A Antigens / genetics
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HLA-A Antigens / immunology*
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HLA-A24 Antigen
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Humans
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Interleukin-2 / pharmacology
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Lymphatic Metastasis / immunology*
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Lymphatic Metastasis / pathology
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Lymphocytes, Tumor-Infiltrating / drug effects
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Lymphocytes, Tumor-Infiltrating / immunology*
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Male
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Middle Aged
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Neoplasms / pathology
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Organ Specificity
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Pleural Effusion, Malignant / immunology
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Pleural Effusion, Malignant / pathology*
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T-Lymphocytes, Cytotoxic / drug effects
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T-Lymphocytes, Cytotoxic / immunology*
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Transfection
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Tumor Cells, Cultured
Substances
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DNA, Complementary
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HLA-A Antigens
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HLA-A*26 antigen
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HLA-A*33 antigen
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HLA-A24 Antigen
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Interleukin-2