Abstract
Methylcholanthrene-induced sarcoma formation in mice was found to be effectively inhibited by the intraperitoneal injection of mistletoe extract (Iscador M). Induction of sarcoma and sarcoma-induced death were inhibited completely at a concentration of 1 mg Iscador/dose. The concentration needed for 50% inhibition was found to be 0.0166 mg Iscador/dose. Mistletoe extract was also found to inhibit lung metastasis induced by B16F10 melanoma cells in mice. Simultaneous administration of the Viscum album extract inhibited lung nodule formation by 92.0% and produced a 71.3% increase in life span.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anticarcinogenic Agents / therapeutic use*
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Antineoplastic Agents, Phytogenic / therapeutic use*
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Female
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Lung Neoplasms / prevention & control
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Lung Neoplasms / secondary
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Melanoma / pathology
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Melanoma / prevention & control
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Mice
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Mice, Inbred C57BL
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Mistletoe*
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Neoplasm Metastasis / prevention & control*
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Phytotherapy*
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Plant Extracts / therapeutic use*
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Plant Proteins*
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Plants, Medicinal*
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Sarcoma, Experimental / drug therapy
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Sarcoma, Experimental / pathology
Substances
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Anticarcinogenic Agents
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Antineoplastic Agents, Phytogenic
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Plant Extracts
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Plant Proteins
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viscum album peptide