Abstract
When injected intraperitoneally in a dose of 8 mg/kg, U-62066, the selective agonist of kappa-opioid receptors, exhibits antiarrhythmic properties in epinephrine-induced arrhythmias in rats. In cerebroventricular injection, the kappa-agonists U-50,488 and [D-ala2]-dynorphin A(1-13) manifest proarrhythmic properties. Preliminary administration of the kappa-antagonist nor-binaltorphimine completely removes the proarrhythmic and antiarrhythmic effect of kappa-agonists. The antiarrhythmic effect of U-62006 is believed to be associated with activation of peripheral kappa-receptors.
Publication types
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Comparative Study
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English Abstract
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetamides / pharmacology
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Acetamides / therapeutic use*
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Animals
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Anti-Arrhythmia Agents / pharmacology
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Anti-Arrhythmia Agents / therapeutic use*
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Arrhythmias, Cardiac / chemically induced
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Arrhythmias, Cardiac / drug therapy
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Drug Evaluation, Preclinical
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Epinephrine
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Ligands
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Male
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Rats
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Rats, Wistar
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Receptors, Opioid, kappa / agonists
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Receptors, Opioid, kappa / antagonists & inhibitors
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Receptors, Opioid, kappa / drug effects*
Substances
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Acetamides
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Anti-Arrhythmia Agents
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Ligands
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Receptors, Opioid, kappa
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Epinephrine