Abstract
The human cytomegalovirus encodes a beta-chemokine receptor (US28) that is distantly related to the human chemokine receptors CCR5 and CXCR4, which also serve as cofactors for the entry into cells of human immunodeficiency virus-type 1 (HIV-1). Like CCR5, US28 allowed infection of CD4-positive human cell lines by primary isolates of HIV-1 and HIV-2, as well as fusion of these cell lines with cells expressing the viral envelope proteins. In addition, US28 mediated infection by cell line-adapted HIV-1 for which CXCR4 was an entry cofactor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS-Related Opportunistic Infections / virology
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Amino Acid Sequence
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Cell Fusion
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Chemokines
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Coculture Techniques
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Cytomegalovirus / genetics*
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Cytomegalovirus / physiology
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Cytomegalovirus Infections / virology
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Giant Cells
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HIV Infections / virology
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HIV-1 / physiology*
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HIV-2 / physiology*
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HeLa Cells
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Humans
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Membrane Proteins / physiology
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Molecular Sequence Data
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Receptors, CCR2
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Receptors, CCR5
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Receptors, CXCR4
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Receptors, Chemokine*
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Receptors, Cytokine / genetics
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Receptors, Cytokine / physiology*
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Receptors, HIV / genetics
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Receptors, HIV / physiology*
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Transfection
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Tumor Cells, Cultured
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Viral Proteins / genetics
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Viral Proteins / physiology*
Substances
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CCR2 protein, human
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Chemokines
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Membrane Proteins
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Receptors, CCR2
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Receptors, CCR5
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Receptors, CXCR4
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Receptors, Chemokine
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Receptors, Cytokine
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Receptors, HIV
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Viral Proteins