Phorbol esters modulate the coupling of the T cell costimulatory molecule CD28 to phosphatidylinositol 3-kinase

Biochem Soc Trans. 1997 May;25(2):305S. doi: 10.1042/bst025305s.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androstadienes / pharmacology
  • Antibodies, Monoclonal / pharmacology
  • Antigens, CD / metabolism*
  • CD28 Antigens / metabolism*
  • CD3 Complex / immunology
  • CD3 Complex / physiology
  • Chromones / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Jurkat Cells
  • Lymphocyte Activation / drug effects
  • Morpholines / pharmacology
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor) / antagonists & inhibitors
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism*
  • T-Lymphocytes / drug effects
  • T-Lymphocytes / immunology*
  • Tetradecanoylphorbol Acetate / pharmacology*
  • Wortmannin

Substances

  • Androstadienes
  • Antibodies, Monoclonal
  • Antigens, CD
  • CD28 Antigens
  • CD3 Complex
  • Chromones
  • Enzyme Inhibitors
  • Morpholines
  • 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Tetradecanoylphorbol Acetate
  • Wortmannin