Abstract
The effect of the organophosphate insecticide Dichlorvos on antioxidant enzymes and other oxidative and redox parameters of carp (Cyprinus carpio L.) and catfish (Ictalurus nebulosus) were studied. Changes in superoxide dismutase, catalase, glutathione peroxidase, and in the case of carp acetylcholinesterase activities were studied in tissue homogenates. Other parameters studied: changes of lipid peroxidation, reduced glutathione and the amounts of two radicals, superoxide and hydroxyl radicals are compared. Our results showed that the organophosphate tested, besides its inhibitory effect on acetylcholinesterase--or together with it--induces changes characteristic of "oxidative stress."
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism
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Animals
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Antioxidants / metabolism*
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Brain / enzymology
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Carps / metabolism*
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Catalase / metabolism
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Dichlorvos / toxicity*
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Female
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Free Radicals
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Glutathione / drug effects
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Glutathione / metabolism
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Glutathione Peroxidase / metabolism
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Hydroxyl Radical
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Ictaluridae / metabolism*
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Insecticides / toxicity*
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Lipid Peroxidation / drug effects
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Male
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Muscles / enzymology
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Myocardium / enzymology
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Oxygen
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Superoxide Dismutase / metabolism
Substances
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Antioxidants
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Free Radicals
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Insecticides
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Hydroxyl Radical
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Dichlorvos
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Catalase
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Glutathione Peroxidase
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Superoxide Dismutase
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Acetylcholinesterase
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Glutathione
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Oxygen