Two cases of bladder cancer in patients with spinal cord injury are reported. A 57-year-old paraplegic woman who had had an indwelling urethral catheter for 20 years visited our hospital with macroscopic hematuria. A bladder tumor was found endoscopically. A transurethral biopsy revealed a squamous cell carcinoma. She refused operation and received radiation therapy. The second case was in a 69-year-old paraplegic man on clean intermittent catheterization for 2 years presenting with a high grade fever. The diagnosis was a transitional cell carcinoma of the urinary bladder. Bilateral cutaneous ureterostomy was performed because of tumor invasion. He received radiation therapy but died of cancer 18 months after surgery.