Abstract
Oosponol [4-(hydroxyacetyl)-8-hydroxy-1H-2-benzopyran-1-one], a toxic metabolite of the basidiomycete Gloeophyllum abietinum, and some synthetic analogues were studied to clarify the molecular basis of their fungicidal, bactericidal, and phytotoxic effects. The antibiotic activity was due to a strong inhibition of RNA and protein synthesis in target cells.
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Basidiomycota / chemistry
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Cell Nucleus / drug effects
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Cell Nucleus / metabolism
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Coumarins / pharmacology*
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Escherichia coli / drug effects
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Escherichia coli / metabolism
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Leucine / metabolism
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Molecular Structure
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Plant Proteins / biosynthesis
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Plants / drug effects
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Plants / metabolism
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Protein Biosynthesis*
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Protoplasts / drug effects
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Protoplasts / metabolism
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RNA / biosynthesis*
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RNA, Plant / biosynthesis
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Transcription, Genetic / drug effects
Substances
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Anti-Bacterial Agents
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Coumarins
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Plant Proteins
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RNA, Plant
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oosponol
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RNA
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Leucine